Preventive Maintenance Service for One (1) Oxford Nanoimaging ONI Nanoimager

Title Preventive Maintenance Service for One (1) Oxford Nanoimaging ONI Nanoimager Description of Requirement The National Institutes of Health (NIH), National Cancer Institute (NCI), intends to award a contract to Oxford Nanoimaging Inc on a sole-source basis pursuant to FAR 6.302-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements, for the acquisition of Annual Service Plan - Nanoimager, the Government intends to solicit and award a Purchase Order on a sole-source basis because the Government's minimum technical requirements will be satisfied by Oxford Nanoimaging Inc. Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active nanoscale extracellular vesicles (EVs). The Translational Nanobiology Section within the Laboratory of Pathology (LP) at the National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research (CCR), is developing new ways to investigate these EVs as biological agents, biomarkers, and therapeutic targets. The section uses an Oxford Nanoimaging (ONI) Nanoimager super-resolution microscope to provide high quality singlemolecule resolution imaging for nanoparticle analysis as part of the section’s EV production and analysis pipeline. Preventive maintenance services are required to ensure its highest peak performance, as this instrument is being used for developing guidelines for best practices in this area of research, and ultimately for establishing a foundation for next-generation EV-based personalized cancer treatment and monitoring. This acquisition is to acquire preventive maintenance services for a super resolution microscope system, Oxford Nanoimaging (ONI) Nanoimager, at the Laboratory of Pathology. Oxford Nanoimaging Inc (ONI) is the original manufacturer and sole provider of authorized maintenance services for the ONI Nanoimager super-resolution microscope. Due to the sensitive nature of the superresolution microscope, i