Tenders

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

DEF ADVANCED RESEARCH PROJECTS AGCY

UPDATE: The purpose of Amendment 1 to DARPA-PA-27-01, the HUBBLE Program Announcement (PA), is to update Attachment B and the verbiage in Section 4.1.2 and Section 7.8 of the Program Announcement. The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.

Future Announcement: Quantum Computing – Applications Workshops (QC-AW)

DEF ADVANCED RESEARCH PROJECTS AGCY

The purpose of this Special Notice (SN) is to provide advance notice of the Defense Advanced Research Projects Agency’s (DARPA’s) intention to host future workshops to determine the commercial impact of future utility-scale quantum computers. Any future Quantum Computing – Applications Workshops (QC-AW) Request for Information (RFI) describing the workshop will be made available at https://sam.gov/.

Atomically Precise Molecules (APM)

DEF ADVANCED RESEARCH PROJECTS AGCY

Amendment 01: The purpose of this amendment is to extend the required abstract deadline. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in the areas of new synthesis techniques for polymeric materials and nonlinear optical (NLO) materials. Proposed research should investigate innovative approaches that enable revolutionary advances in material synthesis with the ability to scale to quantities relevant for application integration, culminating in the development of a prototype demonstration of a revolutionary NLO material integrated into a functional government-provided electro-optic modulator. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice, or research that pivots on exceptional claims that cannot be technically justified in the proposal. This includes: • Proposals aiming to employ solely inorganic materials without a polymeric component • Proposals aiming to modify/repurpose existing NLO materials resulting in incremental improvements to the state-of-the-art (SoA)

Solid-State Energy Conversion from Heat to Electricity Request for Information (RFI)

DEF ADVANCED RESEARCH PROJECTS AGCY

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is requesting information on the current state of the art and technological limitations of solid-state direct thermal-to-electric energy conversion technologies. We define solid state energy conversion as systems that convert a temperature differential directly into electrical energy without utilizing mechanical moving parts (e.g., pistons, turbines, or rotary alternators). This RFI seeks to identify the best possible solid state heat engine performance across a wide operating temperature range, factors that limit performance, and the most attractive use cases if these highly efficient solid state heat engines could be made today. This survey of limits, challenges and use cases will identify opportunities for research and development to inform potential program(s) in this area.

Cattle Run Proposers Day Announcement

DEF ADVANCED RESEARCH PROJECTS AGCY

PROPOSERS DAY: DARPA is hosting a Proposers Day in support of DARPA-SN-27-03 Cattle Run program on Tuesday, November 10, 2026, at the DARPA Conference Center (675 North Randolph Street, Arlington, VA 22203) from 8:00am to 5:00pm EST. The purpose of this conference is to provide information on the Cattle Run program; promote additional discussion on this topic; address questions from potential proposers; and provide a forum for potential proposers to meet for teaming opportunities.

Young Faculty Award (YFA) 2027

DEF ADVANCED RESEARCH PROJECTS AGCY

The Defense Advanced Research Projects Agency (DARPA) Young Faculty Award (YFA) program aims to identify and engage rising stars in junior research positions in academia and equivalent positions at non-profit research institutions, particularly those without prior DARPA funding, to expose them to Department of War (DoW) needs and DARPA’s mission to create and prevent technological surprise for national security. The YFA program provides high-impact funding to researchers early in their careers to develop innovative new research that enables transformative DoW capabilities. Ultimately, the YFA program developes the next generation of researchers focused on national security issues.

Protein Palace Proposers Day

DEF ADVANCED RESEARCH PROJECTS AGCY

The Defense Advanced Research Projects Agency (DARPA) will host an in-person Proposers Day in support of the Protein Palace program on November 17, 2026, at the Executive Conference Center, 4075 Wilson Blvd Ste 300, Arlington, VA 22203, from 9:00 a.m. to 4:00 p.m. ET. DARPA anticipates releasing the Protein Palace solicitation prior to Proposers Day. If released, the Protein Palace solicitation will be made available at https://sam.gov/.

RFI for Next Generation Hypersonic Cruise Missiles

DEF ADVANCED RESEARCH PROJECTS AGCY

Responses to this Request for Information (RFI) will be used to refine the Government's technical requirements, validate programmatic assumptions, and inform the acquisition strategy for a potential competitive Program Solicitation (PS). The primary intent of this RFI is to inform industry of a potential new DARPA program and to encourage innovative contractor/subcontractor teaming arrangements between traditional and non-traditional defense contractors, technology developers, and specialized test and evaluation (T&E) providers prior to formal solicitation.

Unison Proposers Day Announcement

DEF ADVANCED RESEARCH PROJECTS AGCY

PROPOSERS DAY: The Defense Advanced Research Projects Agency (DARPA) Strategic Technology Office (STO) will host a Proposers Day in support of DARPA-PS-27-06, Unison program, on 5 November 2026 at the System Planning and Analysis Research Collaboration Center (SPARCC), 4075 Wilson Blvd., Suite 201 from 9:00AM-2:00 PM EST. The purpose of this conference is to provide information on the Unison program; promote additional discussion on this topic; address questions from potential proposers; and provide a forum for potential proposers to meet potential teaming partners. PROGRAM OBJECTIVE AND DESCRIPTION: The objective of the Unison program is to develop and evaluate collaborative-autonomy approaches that jointly adapt team decision-making and communications during mission execution. Unison will investigate approaches that enable autonomous teams to modify tactics, behaviors, coordination relationships, and information exchange as mission complexity and operational variability increase and communications become extremely constrained and/or degraded.

Nassau Proposers Day

DEF ADVANCED RESEARCH PROJECTS AGCY

The Defense Advanced Research Projects Agency’s (DARPA) Information Processing Techniques Office (IPTO) is sponsoring a Proposers Day in support of the anticipated critical infrastructure resilience program, Nassau, and its anticipated Program Solicitation (PS). The purpose of this event is to provide information on the Nassau technical goals and challenges, address questions from potential proposers, and provide an opportunity for potential proposers to consider how their research may align with the Nassau program objectives. Attendance is voluntary and is not required to propose to the Nassau PS.

JUSTIFICATION FOR OTHER THAN FULL AND OPEN COMPETITION

DEF ADVANCED RESEARCH PROJECTS AGCY

See attached Justification and Approval document for description.

Johns Hopkins University Applied Physics Laboratory (JHU/APL) University Affiliated Research Center (UARC) Support Services

DEF ADVANCED RESEARCH PROJECTS AGCY

Multi X Office (MXO02) Program Support Services

DEF ADVANCED RESEARCH PROJECTS AGCY

This contract action was competed under the General Services Administration (GSA) One Acquisition Solution for Integrated Services Plus, (OASIS+) Unrestricted (Technical and Engineering domain) contract vehicle via GSA eBuy. The resulting award is a hybrid contract type consisting of Cost-Plus-Fixed-Fee (CPFF), Cost-Reimbursement (No Fee), and Labor-Hour (LH) line items. A cost-reimbursement and labor-hour structure was utilized due to the dynamic and evolving nature of the program support required, which precluded the establishment of firm fixed pricing at the time of award.

Pre-Award Synopsis Texas Shield

DEF ADVANCED RESEARCH PROJECTS AGCY

THIS NOTICE IS NOT A REQUEST FOR PROPOSALS OR A COMPETITIVE SOLICITATION. The Defense Advanced Research Projects Agency (DARPA) intends to enter into an Agreement with The University of Texas System consortium of universities in support of the Biological Technologies Office (BTO) LiveChain Program for an integrated research initiative focused on autonomous medical care, casualty evacuation, clinical decision support, and resilient medical supplies in austere and contested environments.

HR001124C0378 DARPA JUSTIFICATION AND APPROVAL FOR OTHER THAN FULL AND OPEN COMPETITION

DEF ADVANCED RESEARCH PROJECTS AGCY

The Ice Control for cold Environments (ICE) program BAA was solicited on August 15, 2022, for the purpose of seeking to develop solutions for extreme cold weather DoW operational challenges by discovering and optimizing biologically sourced or inspired molecules to enable tuned inhibition or nucleation of ice crystallization, propagation, and adhesion. The ICE BAA was solicited for Phase I and Phase II with a notional Phase III that was to be solicited at a later date. This justification provides the rationale for awarding a sole-source modification to the current Phase II contractor, to continue this work into Phase III under the authority of FAR 6.302-1, "Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements."

HR001124C0315 DARPA JUSTIFICATION AND APPROVAL FOR OTHER THAN FULL AND OPEN COMPETITION

DEF ADVANCED RESEARCH PROJECTS AGCY

The Ice Control for cold Environments (ICE) program BAA was solicited on August 15, 2022, for the purpose of seeking to develop solutions for extreme cold weather DoW operational challenges by discovering and optimizing biologically sourced or inspired molecules to enable tuned inhibition or nucleation of ice crystallization, propagation, and adhesion. The ICE BAA was solicited for Phase I and Phase II with a notional Phase III that was to be solicited at a later date. This justification provides the rationale for awarding a sole-source modification to the current Phase II contractor, to continue this work into Phase III under the authority of FAR 6.302-1, "Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements."

Intrinsic Market Resilience (IMR)

DEF ADVANCED RESEARCH PROJECTS AGCY

The evolution of markets from physical trading floors to interconnected, electronic venues has introduced new speed, transparency, and efficiency, but has also created new attack surfaces and systemic risks. Modern markets, which host trading for everything from equities and bonds to energy and cloud computing resources, can be manipulated in ways unanticipated by their designers. The 2010 United States Equity market "flash crash" and the 2000-2001 California energy crisis demonstrated how weaknesses in a market's public interfaces could have dramatic consequences. Similar design issues in today's complex, interacting market systems could be used to cause economic damage, which the IMR program technology seeks to prevent. The IMR program aims to develop repair methods to protect essential economic sectors against devastating attacks that exploit the public interfaces of modern markets. Current legal and regulatory protections focus on deterring profit-seeking manipulation and ensuring compliance, but they do not sufficiently protect markets from adversaries aiming simply to cause disruption. The IMR program seeks to address this gap by developing the tools to automatically model market designs, identify hidden weaknesses, and recommend and analyze repairs on the market models to make markets fundamentally more resilient to attack. IMR aims to combine Large Language Model (LLM)-based automation with rigorous modeling and analysis to identify remediations for market weaknesses. The program will develop formal notations to precisely describe how markets operate and coordinate, creating machine-analyzable models from informal descriptions like regulatory filings and technical specifications. Against these models, IMR will formulate and assess "resilience conjectures” - mathematical statements about desirable market properties, such as the inability for actors to manipulate prices without risking loss. By automatically analyzing these conjectures, the program ai

DARPA Surgical Competition (DSC) Second Industry Day

DEF ADVANCED RESEARCH PROJECTS AGCY

The Biological Technologies Office (BTO) of the Defense Advanced Research Projects Agency (DARPA) will host a Second Industry Day for potential competitors in the DARPA Surgical Competition (DSC). The Second Industry Day will be held on Wednesday November 4th, 2026, from 4:00 PM to 6:00 PM virtually. Advance registration is required. Note: all times listed in this announcement and on the registration website are Eastern Time.